Airway Systems Virology Lab Systems Biology of Susceptibility and Responses to Respiratory Viruses

Research

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat.

Highlighted

Three modes of viral adaption by the heart
Three modes of viral adaption by the heart
Cameron D. Griffiths, Millie Shah, William Shao, Cheryl A. Borgman, Kevin A. Janes
Science Advances  ·  15 Nov 2024  ·  doi:10.1126/sciadv.adp6303

All

2026

Epigenetic remodeling of the nasal epithelium in chronic rhinosinusitis: Histone deacetylase 7 HDAC7 mediates type 2 inflammation
Epigenetic remodeling of the nasal epithelium in chronic rhinosinusitis: Histone deacetylase 7 (HDAC7) mediates type 2 inflammation
Cameron D. Griffiths
Annals of Allergy, Asthma & Immunology  ·  01 May 2026  ·  doi:10.1016/j.anai.2026.02.014
Prevalence and Predictors of Eosinophilic Esophagitis EoE Among Children With Severe Asthma
Prevalence and Predictors of Eosinophilic Esophagitis (EoE) Among Children With Severe Asthma
Erica Licari, Larry C. Borish, Soutik Ghosal, Cameron Griffiths, Barrett H. Barnes, Ariana Greenwell, Jeremy P. Middleton, W. Gerald Teague, Emily C. McGowan
The Journal of Allergy and Clinical Immunology: In Practice  ·  01 Mar 2026  ·  doi:10.1016/j.jaip.2026.02.030

2025

Systems virology at scale
Systems virology at scale
Cameron D. Griffiths, Andrew J. Sweatt, Kevin A. Janes
Current Opinion in Systems Biology  ·  01 Dec 2025  ·  doi:10.1016/j.coisb.2025.100562
A single amino acid mutation alters multiple neutralization epitopes in the respiratory syncytial virus fusion glycoprotein
A single amino acid mutation alters multiple neutralization epitopes in the respiratory syncytial virus fusion glycoprotein
Ahmed K. Oraby, Aleksandra Stojic, Farah Elawar, Leanne M. Bilawchuk, Ryley D. McClelland, …, Frederick. G. West, Octavio Ramilo, Asuncion Mejias, Jason S. McLellan, David J. Marchant
npj Viruses  ·  22 Apr 2025  ·  doi:10.1038/s44298-025-00119-8

2024

Three modes of viral adaption by the heart
Three modes of viral adaption by the heart
Cameron D. Griffiths, Millie Shah, William Shao, Cheryl A. Borgman, Kevin A. Janes
Science Advances  ·  15 Nov 2024  ·  doi:10.1126/sciadv.adp6303
Exacerbations of Mild Asthma Are Common: Results From a Large Community-Based Sample
Exacerbations of Mild Asthma Are Common: Results From a Large Community-Based Sample
W. Gerald Teague, Cameron D. Griffiths
The Journal of Allergy and Clinical Immunology: In Practice  ·  01 Oct 2024  ·  doi:10.1016/j.jaip.2024.07.033
A novel syndrome of silent rhinovirus-associated bronchoalveolitis in children with recurrent wheeze
A novel syndrome of silent rhinovirus-associated bronchoalveolitis in children with recurrent wheeze
W. Gerald Teague, Cameron D. Griffiths, Kelly Boyd, Stella C. Kellams, Monica Lawrence, …, Jacqueline Payne, Marthajoy Spano, Elaine Etter, Brittany Wall, Larry Borish
Journal of Allergy and Clinical Immunology  ·  01 Sep 2024  ·  doi:10.1016/j.jaci.2024.04.027
Utility of TH2 cell biomarkers to predict outcomes and treatment response in children with asthma
Utility of TH2 cell biomarkers to predict outcomes and treatment response in children with asthma
W. Gerald Teague, Cameron Griffiths
Journal of Allergy and Clinical Immunology  ·  01 Jul 2024  ·  doi:10.1016/j.jaci.2024.04.023

2023

Actin cytoskeleton remodeling disrupts physical barriers to infection and presents entry receptors to respiratory syncytial virus
Actin cytoskeleton remodeling disrupts physical barriers to infection and presents entry receptors to respiratory syncytial virus
Quinten J. Kieser, Madison J. Granoski, Ryley D. McClelland, Cameron Griffiths, Leanne M. Bilawchuk, Aleksandra Stojic, Farah Elawar, Kyla Jamieson, David Proud, David J. Marchant
Journal of General Virology  ·  28 Nov 2023  ·  doi:10.1099/jgv.0.001923
Proteome-wide copy-number estimation from transcriptomics
Proteome-wide copy-number estimation from transcriptomics
Andrew J. Sweatt, Cameron D. Griffiths, B. Bishal Paudel, Kevin A. Janes
openRxiv  ·  11 Jul 2023  ·  doi:10.1101/2023.07.10.548432

2021

Simulating coxsackievirus B3 infection with an accessible computational model of its complete kinetics
Simulating coxsackievirus B3 infection with an accessible computational model of its complete kinetics
Cameron D. Griffiths, Andrew J. Sweatt, Kevin A. Janes
STAR Protocols  ·  01 Dec 2021  ·  doi:10.1016/j.xpro.2021.100940

2020

IGF1R is an entry receptor for respiratory syncytial virus
IGF1R is an entry receptor for respiratory syncytial virus
Cameron D. Griffiths, Leanne M. Bilawchuk, John E. McDonough, Kyla C. Jamieson, Farah Elawar, …, Anil Kumar, Tom C. Hobman, David Proud, Theo J. Moraes, David J. Marchant
Nature  ·  03 Jun 2020  ·  doi:10.1038/s41586-020-2369-7

2017

A Virological and Phylogenetic Analysis of the Emergence of New Clades of Respiratory Syncytial Virus
A Virological and Phylogenetic Analysis of the Emergence of New Clades of Respiratory Syncytial Virus
Farah Elawar, Cameron D. Griffiths, Daniel Zhu, Leanne M. Bilawchuk, Lionel D. Jensen, Lydia Forss, Julian Tang, Bart Hazes, Steven J. Drews, David J. Marchant
Scientific Reports  ·  25 Sep 2017  ·  doi:10.1038/s41598-017-12001-6
The Susceptibilities of Respiratory Syncytial Virus to Nucleolin Receptor Blocking and Antibody Neutralization are Dependent upon the Method of Virus Purification
The Susceptibilities of Respiratory Syncytial Virus to Nucleolin Receptor Blocking and Antibody Neutralization are Dependent upon the Method of Virus Purification
Leanne Bilawchuk, Cameron Griffiths, Lionel Jensen, Farah Elawar, David Marchant
Viruses  ·  03 Aug 2017  ·  doi:10.3390/v9080207
Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment
Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment
Cameron Griffiths, Steven J. Drews, David J. Marchant
Clinical Microbiology Reviews  ·  01 Jan 2017  ·  doi:10.1128/cmr.00010-16